She previously served as Uganda's representative to the Nordic countries, the United States, the African Union, Ethiopia and Djibouti.
In 1986, following the change of government in Kampala, she was named Uganda's ambassador to the Nordic countries, based in Copenhagen, Denmark, serving in that capacity for 10 years.
In 1996, she was named Uganda's ambassador to the United States, based in Washington, D.C.. She served in that capacity for another 10 years.
[1][3] In 2015, she was named by the Secretary-General of the United Nations to serve on the Advisory Group of Experts on Review of Peacebuilding Architecture.
[5] Edith Grace Sempala is married to Patrick Ssempala, although they have been separated since 1996 and she has been seeking a divorce.