[3] Matthysse made her professional debut on 18 May 2007, scoring a four-round unanimous decision (UD) victory against Graciela Adriana Becerra at the Estadio Socios Fundadores in Comodoro Rivadavia, Argentina.
[4] After compiling a record of 9–3–1 (1 KO), she challenged Yazmín Rivas for the IBF female bantamweight title on 4 February 2012, at the Gimnasio de las Liebres in Río Bravo, Mexico.
[5] Following a UD victory against Antonia Ayala Vazquez in March,[6] Matthysse faced former two-weight world champion Marcela Acuña on 10 May 2013, at the Auditorio Presidente Néstor Kirchner in Tapiales, Argentina, with the vacant IBF Inter-Continental female super bantamweight title on the line.
[9] In her next fight she challenged WBA female featherweight champion Ogleidis Suárez on 13 December 2013, at the Teatro Griego Juan Pablo Segundo in San Martín, Argentina.
[13] The pair would have a rematch on 11 March 2016, at the Shaw Conference Centre in Edmonton, Canada, with Mrdjenovich gaining her revenge, dropping Matthysse to the canvas in the tenth and final round en route to a UD victory.