Edmund O'Reilly (b. at Dublin, 3 January 1598; d. at Saumur, France, 8 March 1669) was an Irish prelate of the Roman Catholic Church.

After ordination he studied at the Catholic University of Leuven, where he held the position of prefect of the college of Irish Secular Ecclesiastics.

[2] In 1653, ordered to quit the country, he took refuge at the Irish College of Lisle where he was notified of his appointment to the See of Armagh, and shortly after consecrated at Brussels.

At Rome he was able to vindicate himself, but he was not allowed to return to Ireland by the English authorities until 1665, and then only in the hope that he would favour the Remonstrance of Peter Valesius Walsh.

O'Reilly, like the great majority of the Irish bishops and priests, rejected it, nor could the entreaties of Walsh or the threats of James Butler, 1st Duke of Ormonde change him.