In 1841 he began practice as a physician in Hanover, and a year later became Professor of Anatomy and Physiology at Dartmouth.

City, and in 1858 (in which year he removed his residence from Hanover to New York) he accepted the Professorship of Obstetrics in the same institution, which he held until 1860.

From the date of his removal to New York he took a leading position in his profession, making a specialty of the diseases of women, and particularly of ovariotomy.

He also published in 1854 a work on Human Histology, and was a frequent and valued contributor to the medical journals.

After an unusually exhausting series of professional engagements, he was attacked with pneumonia, and died after a week's illness, January 21, 1878, aged 64 years.