Edna Sarah Cole (January 1, 1855 – November 23, 1950) was an American Presbyterian missionary who worked in Siam (Thailand) from the late 19th through early 20th centuries.

Margaret Landon consulted Cole's letters home to her sister in the United States in her research for writing Anna and the King of Siam.

[1] Cole became a Presbyterian missionary under the auspices of the Board of Foreign Missions in 1875, and sailed for southeast Asia that year.

[15][16] Cole retired in 1923,[1] but stayed in Bangkok for several years afterwards, and was an honored attendee at an event marking the centenary of Protestant missions in Siam in 1929.

[18] Her students included Sangwan Talaphat—the future Princess Mother Srinagarindra—who studied English with Cole before pursuing further education in the United States and meeting Prince Mahidol Adulyadej.