Mondino qualified in journalism at the Colegio Universitario de Periodismo Obispo Trejo y Sanabria in Córdoba.
Following several years working in social communications in his province, he joined the state gas company in 1989.
On 14 May 1995, Mondino was elected to the Argentine Chamber of Deputies, representing Córdoba Province at the head of the Justicialist Party list.
On several occasions, Mondino made clear his intention to compete for the governorship of Córdoba following the end of his term as Ombudsman in December 2009, leaving him two years ahead of the 2011 elections.
In April 2009, Mondino announced his early resignation as Ombudsman in order to allow him to compete in the 28 June legislative elections for Senator for Córdoba.