A member of a group known as the Generation of '80, he founded the National Museum of Fine Arts in Buenos Aires and sparked the development of painting in his country.
In 1884 he travelled to Europe as correspondent for the newspaper El Diario, publishing various articles on artistic themes under the pseudonym Zig Zag.
In 1891 he was one of the founders of the Buenos Aires Athenaeum, a group dedicated to renewing Hispanic American culture through the participation of distinguished figures like Rubén Darío and Leopoldo Lugones.
He acted as its first director until 1910, and secured Auguste Rodin's contribution of numerous sculptures for newly established parks in Buenos Aires.
Schiaffino was afterwards engaged in various diplomatic undertakings in Europe, but in 1933 he returned to Buenos Aires and published his most important book, Painting and Sculpture in Argentina.