Coming from a family of politicians, his father, an uncle and also one of his brothers all served as mayors of Pigkawayan, North Cotabato.

Eduardo V. Roquero began as a Rural Health Physician and NGO Family Planning Physician of San Jose del Monte in the 1980s, at that time, he was also the owner and director of Roquero General Hospital.

He served as Municipal Mayor of San Jose del Monte from 1988–1992 and 1994–2000 and City Mayor of San Jose del Monte from 2000–2004 and 2007–2009, making him the first city mayor from the time San Jose del Monte was converted from a municipality in 2000 to become the province's first component city.

Known as the Brain and Father of Cityhood and the Man behind San Jose del Monte's Golden Age of Governance,[citation needed] Hon.

A year after his death in 2009, he was given the "Dangal ng Lahing San Jose Award" which is the highest form of recognition to a public servant.