Edward A. Keenan (October 15, 1894 – April 12, 1970) was an American politician who served as the 34th Mayor of Burlington, Vermont.

Keenan was the last Republican elected to the mayoralty of Burlington until Peter C. Brownell was thirty years later.

[6] In 1963 incumbent Mayor Robert K. Bing announced that he would not seek a second term and party officials asked Keenan to run for mayor, but refused to make a decision until January 30, 1963, when he announced that he would run and received Bing's endorsement.

[16][17] Keenan was unable to campaign for state senate due to being hospitalized and the initial results of the election showed him losing by one vote.

[21] The city hall flag in Burlington was flown at half-staff until after his funeral services by the orders of Francis J. Cain.