Francis J. Cain (December 20, 1922 – March 14, 2019) was an American politician and insurance agent who served as the 35th Mayor of Burlington, Vermont.

[4] In 1962, Cain was elected as an alderman from city ward one to succeed William L. Wright who was not seeking reelection.

[12][13] After leaving the mayoralty Cain was elected to the presidency of the Greater Burlington Improvement Corporation which he served as until 1973.

[15] In 1975 Cain was appointed to the Lake Champlain Regional Chamber of Commerce and two years later was elected as its president.

On March 14, 2019, Cain died at his home in Shelburne, Vermont and was later called "the godfather of what is modern Burlington."