Edward Augustus Holyoke (August 1, 1728 – March 31, 1829) was an American educator and physician.

[2] He died in Salem, Massachusetts in 1829 at the age of 100, surpassing the average life expectancy at the time by fifty years.

[3] Holyoke was a charter member of the American Academy of Arts and Sciences[4] and the president of the organization from 1814 to 1820.

The length of his service to the medical practice and his pioneering work in the advancement of smallpox vaccinations have been acknowledged.

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