Edward Butler Osborne (August 3, 1814 Northampton, Hampshire County, Massachusetts – July 20, 1893 Albany, New York) was an American newspaper publisher and politician from New York.
He learned the printer's trade at the Northampton Gazette, and then worked for the Salem Landmark.
In 1853, he bought the Poughkeepsie American and renamed it the Dutchess Democrat.
In 1856, he merged his paper with the Poughkeepsie Telegraph, and published it until 1883, when he retired.
He was found dead in his bed on the morning of July 20, 1893, at his lodgings in Clinton Avenue, in Albany.