He trained as a surgeon, but was appointed head of the London Veterinary College in its early years.
Edward Coleman (the younger) was apprenticed to Dr Kite at Gravesend and, in 1789, went to London to the Borough School of Medicine residing in the family of Henry Cline F. R. S., surgeon to Guy's Hospital.
During his training Coleman studied asphyxia and gained a prize for an essay on Resuscitation awarded by the Humane Society, published in 1791.
He relinquished the Ordnance position in 1816, but remained Principal Veterinary Surgeon of the Army until his death.
Coleman died of gout and liver disease 14 July 1839 and was buried in the churchyard of St James's Hampstead Road.