[1] A scion of a prominent Hudson River family,[2] Ludlow was born in 1810 on Greenwich Street in New York City, which was a fashionable residential area at the time.

[6] Ludlow studied medicine and duly received his degrees and diploma from the College of Physicians and Surgeons in 1831 before becoming a medical doctor.

[3] In 1850, however, he returned to New York and went into partnership with General Edward Jones Mallett (former Consul-General to Italy during the U.S. Civil War)[7] until Mattlett's retirement in 1856.

[10] Around early 1884, he took an active interest in forming the New York Real Estate Exchange and Auction Room, becoming its president and continuing as one of the "controlling spirits in that organization up to the time of his death.

Situated next to Northwood (her brother Robert Edward Livingston's estate), Pine Lawn was the furthest north of the five subdivisions his father-in-law made to his children.

Dr. Charles Comfort Tiffany was held at the Zion Church at Madison Avenue and 38th Street, his remains were interred in the family vault at Tivoli.