In 1831 he was elected to the House of Commons for Flintshire, a seat he held from 1831 to 1837, from 1841 to 1842 and from 1847 to 1850.
In 1854 he succeeded his father in the barony and entered the House of Lords.
Lord Mostyn married Lady Harriet-Margaret Scott on 20 June 1827.
Lady Mostyn was the eldest daughter of the Earl of Clonmel.
Lord Mostyn died in March 1884, aged 89, and was succeeded in his titles by his grandson Llewellyn, his eldest son the Hon.