Edward Lloyd IV (December 15, 1744 – July 8, 1796) was an American planter from Talbot County, Maryland.

From 1771 to 1774, he was a member of the General Assembly and in the Maryland State House of Representatives in 1780.

In 1771 Lloyd purchased the Chase–Lloyd House in Annapolis, Maryland from Samuel Chase, and in 1790 he built Wye House on the family plantation near Easton, Maryland.

Elizabeth's brother and successor to the wealthiest planter moniker, John Tayloe III, built The Octagon House in Washington, DC at the behest of George Washington.

Their son, also Edward Lloyd, was later Governor of Maryland, and a U.S.