Sir Edward Loftus (1563–1601) was an Irish barrister, judge and soldier of the Elizabethan era.
He was also a professional soldier who fought in the Nine Years War, and was knighted for his services to the English Crown by Robert Devereux, 2nd Earl of Essex, in 1599.
He married Anne Duke, daughter and co-heiress with her sister Mary of Sir Henry Duke of Castlejordan, County Meath and his wife Elizabeth Brabazon, daughter of Sir William Brabazon, Vice-Treasurer of Ireland and his wife, the much-married heiress Elizabeth Clifford.
She died in childbirth shortly after Edward's death; their only child, a daughter, lived just a few days.
Edward and Anne are buried in the family vault which his father had built in St. Patrick's Cathedral, Dublin.