Edward Ludlow Wetmore (March 24, 1841 – January 19, 1922) was a Canadian judge and politician.
Born in Fredericton, New Brunswick, the son of Charles Peters Wetmore and Sarah Burr Ketchum, he received a Bachelor of Arts degree from the University of New Brunswick in 1859.
He was elected to Legislative Assembly of New Brunswick and was Leader of the Opposition from 1883 to 1886.
In 1907, he became the first Chancellor of the University of Saskatchewan and served in this position until 1917.
He died in Victoria, British Columbia on January 19, 1922.