Edward Mussey Hartwell (1850–1922) was an American academic who taught at Johns Hopkins University.

Edward M. Hartwell attended Lawrence Academy before graduating from the Boston Latin School, after which he enrolled at Amherst College.

He left Boston to pursue medical studies at Miami Medical College in Cincinnati in 1877, but chose to enroll at Johns Hopkins University the next year for biology.

He then joined the Hopkins faculty as associate in physical training and director of the gymnasium.

[1] Hartwell was named an inaugural fellow of the American Statistical Association in 1914, and died in 1922.