Their only son, Edward William Cornelius Humphrey, became a legal expert and representative to the national Presbyterian General Assembly.

[citation needed] Humphrey grew up in Connecticut, and he trained for college at the Amherst academy.

In 1833 he graduated at the Andover Theological Seminary, and in 1834 he answered the call to begin his ministry as pastor of a Presbyterian church in Jeffersonville, Indiana.

[3] He received the degree of Doctor of Divinity from Hanover College in Indiana in 1852, and in 1853 he was named by the General Assembly of the Presbyterian Church as a professor in Princeton Theological Seminary.

He declined the professorship at the Princeton Seminary but accepted one offered as Professor of Church History at the Theological College in Danville, Kentucky.

In the later years of his residence in Danville, his health began to fail, perhaps because of the ongoing American Civil War.

[3] In 1848, he gave the dedicatory address for Cave Hill Cemetery, saying, "Let the place of graves be rural and beautiful.