Edward Vaughan (or Wagham) (died 1522) was a Welsh bishop of St David's, remembered for construction work in his diocese.
He built a house near St. Paul's for his successors in the treasurership, and distributed five hundred marks to the poor in London in time of dearth.
He was made archdeacon of Lewes in 1509, and on 22 July in the same year, vacating his London appointments, he was consecrated bishop of St. David's, to which he was promoted by the pope's bull of provision dated 13 January 1509.
On its walls he placed three coats-of-arms his own, those of Henry VII, and of Sir Rhys ap Thomas, probably a past patron, and who spent his latter days at Carew Castle, close to Lamphey, at that time an episcopal residence.
Vaughan died in November 1522, and was buried in the chapel which he built and which bears his name.