Born at Greenford, Middlesex, he was son of Francis Waterhouse of that place, by his wife Bridget, daughter of Morgan Powell; Sir Edward Waterhouse was his great-uncle.
He was admitted in 1635 to Emmanuel College, Cambridge, where he graduated Legum Doctor (LLD) per literas regias in 1668.
[1] In the time of the Commonwealth he lived for some years at Oxford in order to pursue studies in the Bodleian Library.
[1] Through Gilbert Sheldon, archbishop of Canterbury, he took holy orders in 1668, and became a preacher.
He died on 30 May 1670 at his house at Mile End Green, and was interred on 2 June at Greenford, where he had an estate.