[6] He undertook a PhD, supervised by professor Sarah Tabrizi, at the UCL Institute of Neurology, Queen Square, London,[7] during which he published research on biomarkers for Huntington's disease using magnetic resonance imaging measures of brain atrophy[8][9][10][11] and biochemical analysis of blood.

His work has shown that NFL has better prognostic value in Huntington's disease, but that mutant huntingtin might be a valuable marker for early and sensitive detection of change in clinical huntingtin-lowering trials.

[25][24] He was a senior investigator in the clinical programme studying the antisense oligonucleotide tominersen to lower mutant huntingtin production in HD,[26] and gave the first dose of the drug to a patient in 2015.

[38] In 2010, with Jeff Carroll, Wild founded HDBuzz, an online source of accessible news about Huntington's disease research,[39][40] that has received awards from patient advocacy groups.

[44][45] Wild appeared in the documentary feature film The Inheritance[46][47] and was a judge for the 2015 British Library / Europe PubMed Central 'Access to Understanding' contest for science writers.

[52][53] In 2021, he wrote the afterword of Patient 1,[54] a book by Charlotte Raven about her experiences with Huntington's disease, including her participation on the trial of the experimental drug tominersen.