As research branch chief for Western Electric in the early 1900s, he and scientists under his direction achieved significant advances in the development of oscillators and vacuum tube push–pull amplifiers.
Colpitts died at home in 1949 in Orange, New Jersey, United States and his body was interred in Point de Bute, New Brunswick, Canada.
Born in Point de Bute, New Brunswick, he began his education at Mount Allison University and was later a teacher and school principal in Newfoundland.
Colpitts served in the US Army Signal Corps during World War I and spent some time in France as a staff officer involved with military communication.
They summarized work on bandpass filters and vacuum-tube electronics, which had enabled a four-channel commercial system to be placed in operation between Baltimore, MD, and Pittsburgh, PA, in 1918.