In the 2017 Kenyan general election, Edwin Sifuna expressed his interest to vie[4] for the Kanduyi Constituency Member of Parliament seat on an ODM Party ticket.

With only about two months to the general elections in August, ODM fronted[5] Sifuna as their preferred candidate to contest the Nairobi senatorial seat[6] then held by Mike Sonko.

In February 2018, Sifuna was picked as the Secretary-General of ODM[7] party to replace Ababu Namwamba.

In the 2022 Kenyan general election, Sifuna once again [9][10] contested the Nairobi Senatorial seat.

His father was a civil servant with the defunct Municipal Council and his mother, a now-retired teacher from Moi Primary School in Bungoma.