He later invested in and developed properties in cities in the southern United States, including Atlanta, Georgia, and Asheville, North Carolina.

[4] Although complete contents of the original tablets were not revealed, later formulations contained (in addition to quinine and bromide) phenolphthalein as the laxative, an analgesic such as acetanilide or phenacetin, and medicinal plant extracts.

The Bromo Quinine cold tablets were sold in a package that bore Grove's signature, thereby ensuring the buyer of the product's authenticity and implied quality.

In 1891, Grove moved his business to St. Louis, Missouri, a railroad center and inland port city, so he could more easily ship his product nationwide.

In 1897, after his doctors' urgings, Grove built a summer home in Asheville, North Carolina, amid the clean mountain air.

He also began construction of the Grove Arcade, an indoor mall of the sort common in Western Europe, which was completed in 1929 after his death.

In 1927, Grove died at the Battery Park Hotel in Asheville with funeral services held in the city's First Presbyterian Church, of which he was a member.