Edwin Willits (also Willets) (April 24, 1830 – October 22, 1896) was a politician from the U.S. state of Michigan.

Willits served as prosecuting attorney of Monroe County, Republican from Michigan's 2nd congressional district for the 45th, 46th, and 47th Congresses.

The first Assistant U.S. Secretary of Agriculture under Jeremiah McLain Rusk for Benjamin Harrison's administration.

Willits served as prosecuting attorney of Monroe County from 1860 to 1862 and was a member of the State board of education from 1860 to 1872.

In Benjamin Harrison's administration, he served as the first Assistant U.S. Secretary of Agriculture under Jeremiah McLain Rusk from March 23, 1889 to December 31, 1893.