He continued his father's policy of good relationships with the Franconian line of the House of Hohenzollern, who ruled the Burgraviate of Nuremberg and the Margraviate of Brandenburg.

In 1482 in Berlin, he married Magdalena, the daughter of Margrave Friedrich of the Altmark, thus creating a family relationship between the two lines of Hohenzollern.

Eitel Friedrich II was a close friend of Maximilian I and maintained excellent relations with the House of Habsburg.

He distinguished himself in the Battle of Guinegate in 1479 and in 1488, he led the vanguard against rebellious citizens of Bruges, who held the newly elected Emperor captive.

In 1499, Eitel Friedrich and Dietrich Blumeneck led a small army against Switzerland and conquered Rorschach on the south bank of Lake Constance.