It also has paintings by: George Winter, Thomas Hill, Albert Bierstadt, Charles King, and Olaf Seltzer.

In another room, there is a large collection of paintings by New Mexico-associated painters, such as: Joseph Henry Sharp, William Victor Higgins, Ernest L. Blumenschein ("Penitentes"), John French Sloan, and Georgia O'Keeffe (“Taos Pueblo”).

This gallery is dedicated to the 57-piece collection of traditional Western art donated to the museum by the George Gund Family.

In 2021, a six-person panel of American Institute of Architects (AIA) Indianapolis members identified the museum among the ten most "architecturally significant" buildings completed in the city since World War II.

[6] The museum offers the prestigious Eiteljorg Contemporary Art Fellowship (formerly called the Eiteljorg Fellowship for Native American Fine Art) biennially to recognize some of the most innovative and influential contemporary Native artists active today.