[4] El Seibo is one of the oldest towns in the country, it was created by the Constitution of November 6, 1844 although it already existed as a territorial division since colonial times, for this reason its foundation dates back to 1502 by the Spanish conqueror Juan de Esquivel.

A cross called Asomante is still preserved, in the West Sector of the city of El Seibo.

It is currently the second cocoa-producing province, it is estimated that it produces about 132,000 quintals of cocoa per year, which contributes significantly to the economy of its municipalities.

Some of the distinguished people from El Seibo include Manuela Díez, mother of Juan Pablo Duarte, Cesáreo Guillermo and Alexander Woss y Gil, who were Presidents of the Republic.

In addition, Monsignor Octavio A. Beras, Archbishop of Santo Domingo and Cardinal of the Catholic Church and Minerva Bernardino, who represented the country in several international events and defended women's rights, were also from Santa Cruz del Seibo, as well as world-renowned and respected tenor, Francisco Chahin Casanova.