Located in north-central Dominican Republic, in the Cibao region, it is bordered by the provinces of Valverde to the north-west, Puerto Plata to the north, Espaillat and La Vega to the east, San Juan to the south and Santiago Rodríguez to the west.

Santiago is home to one of the largest medical centers in the country, Clínica Unión Médica, which serves all 14 provinces of El Cibao.

Santiago province is located in a valley within the Northern Cordillera that crosses the entire north of the country and also is the Diego de Ocampo peak of 1,249 meters above sea level.

The main river that crosses Santiago is the Yaque del Norte, which borders the entire southern part of the province.

Santiago was founded in 1495, originally on the banks of the Yaque del Norte River, but it is not yet very clear why it was moved in 1504 to the rural community of Jacagua, at the foot of the Diego de Ocampo peak.

Industries of all kinds are concentrated in Santiago de los Caballeros More than a million people from different parts of the region and the country move daily.

Located in the heart of the island, Santiago is endowed with agile access roads, being 2 hours from Santo Domingo and 45 minutes from Puerto Plata, both cities with important ports and airports for the transport of merchandise and passengers to and from abroad.

Internal production is broad in a diverse range of activities, such as cigarettes, shoes, leather, meat food processors, food packaging industries (vegetable and vegetable fats), metal-mechanics, packaging, ceramics, crafts and materials of construction such as cement factory, blocks, windows, doors and others.

By 1995, it had a workforce of 32,000 jobs, distributed in 79 companies that manufacture textiles, cigarettes, shoes, plastics, leather, communications, electrical equipment, among others.

A broad and productive class of merchants, an efficient banking system, communications, tourism, professionals from various disciplines, contribute greatly to the economic and social development of the Dominican Republic.