Produced by Corpa Publicidad, sponsored by Lucky Strike Cigarettes (later by Añejo Santa Teresa, a brand of rum), and hosted exclusively by Víctor Saume, this program began in mid-1954 and was shown between 12:00 noon and 1:30pm, Mondays and Saturdays.
The show was also hosted by Héctor Monteverde, Félix Cardona Moreno, Charles Barry, and Luis Brito Arocha.
El Show de las Doce brought to its audience international superstars such as Pedro Infante, Libertad Lamarque, Olga Guillot, Celia Cruz and La Sonora Matancera, La Tongolele, Miguel Aceves Mejía and Lola Flores.
Venezuelan artists who appeared on the show included Alfredo Sadel, Héctor Cabrera, Los Torrealberos, Magdalena Sánchez, Rosa Virginia Chacín, Cherry Navarro, and Chelique Sarabia.
At the beginning of 1964, it was found that Saume had some respiratory problems, and the show ended on March 15, 1964, eight months before his death.