He died on 15 April 1957 in Mérida, Yucatán, while en route to Mexico City when his plane crashed due to engine failure.

[1][4] As a teen, Infante showed talent and affection for music, made his own guitar in a carpenter shop, played in the Luis Ibarra Orchestra led by his father, and formed his own band called La Rabia (The Anger) in 1933.

Ernesto Belloc, the station's artistic director at the time, advised Infante to continue his career as a carpenter, as he was nervous during the audition.

[11] In Mexico City, he sang the songs of composers including Alberto Cervantes, José Alfredo Jiménez, Cuco Sánchez, Tomás Méndez, Rubén Fuentes, (some of the most renowned composers from the golden age of Mexican Cinema) Salvador Flores Rivera (Chava Flores) (better known for his humorous songs), René Touzet and others.

Infante first appeared as an extra in the movie En un Burro Tres Baturros (Three Men from Aragon on a Donkey), or the more correct and succinct transliteration, "Three Baturros on a Burro.” His career as an actor in leading roles started with La Feria de Las Flores (The Fair of Flowers), literally translated as "The Flower Carnival," in 1943.

In that same year, Mexican writer Carmen Barajas Sandoval, a friend and neighbor of Infante's wife, offered to introduce them to Jorge Negrete, a singer he admired.

Some of his most popular songs include: Amorcito Corazón (approximately My Little Love, Sweetheart), Te Quiero Así (I Love You Like This), La Que Se Fue (She Who Left), Corazón (Heart), El Durazno (The Peach), Dulce Patria (Sweet Fatherland), Maldita Sea Mi Suerte (Cursed Be My Luck), Así Es La vida (Life Is Like This), Mañana Rosalía (Tomorrow Rosalía), Mi Cariñito (My Little Darling), Dicen Que Soy Mujeriego (They Say I Am A Womanizer), Carta a Eufemia (Letter to Eufemia), Nocturnal, Cien Años (Hundred Years), Flor Sin Retoño (Flower Without Sprout), Pénjamo, and ¿Qué Te Ha Dado Esa Mujer?

[24] The world-famous song Bésame Mucho ("Kiss Me a Lot", or more loosely translated to get its elusive Spanish meaning closer to its English meaning, "Give Me a Lot of Kisses"), from the composer Consuelo Velázquez, was the only melody that he recorded in English and he interpreted it in the movie A Toda Máquina (ATM) (At Full Speed), with Luis Aguilar.

[11] Infante's hobby was aviation, logging 2,989 flight hours, under the pseudonym Captain Cruz, which then led to his death on the morning of 15 April 1957.

According to Wilbert Alonzo-Cabrera, his biographer, the actor was co-piloting a Consolidated B-24D, which had been converted from heavy bomber to freighter in San Diego, California.

[25] The death of Pedro Infante caused an unprecedented outpouring of grief in Mexico and Latin America leading to reports of suicides, faintings, and nervous breakdowns among his fans.

[28][29] Two days later he was laid to rest at the Panteón Jardín cemetery amid 300,000 people who had come for the gathered to the closed casket funeral after a tribute at the Jorge Negrete Theater.

[33] On 2 April 2001, Infante was inducted into the International Latin Music Hall of Fame in an awards ceremony that also included Xavier Cugat and Ruben Blades.

Infante attracts a great number of fans of every age to his shrine in the Panteón Jardín of Mexico City, as well as the one at 54th and 87th streets in the historic center of Mérida.

Denise Chávez, said in her book Loving Pedro Infante: "If you're a [Mexican], and don't know who he is, you should be tied to a hot stove with a yucca rope and beaten with sharp dry corn husks as you stand in a vat of soggy fideos.