[1] After an internship at Georgetown University she joined NCI as a resident in anatomic pathology, and has been a senior investigator since 1974, focusing on the classification and definition of lymphomas.

[5] Today, her research includes genetic and epigenetic studies aimed at understanding how B-cells become Hodgkin's lymphoma cells, particularly through the lens of the microenvironment.

[6] In her second year of medical school, she met and married her husband Michael Evan Jaffe, then a law student.

Jaffe and her fellow NCI researchers showed that red blood cells coated with antibody and erythrocyte-antibody-complement (EAC) adhered to B-cell areas, proving they were lymphocytes derived from the lymphoid follicles.

[6] She has also served as president of the Society for Hematopathology[6] and the United States and Canadian Academy of Pathology (USCAP) (from 1998 to 1999).