Eldred Simkins (August 30, 1779 – November 17, 1831) was a U.S. Representative from South Carolina.
He was admitted to the bar in 1805 and commenced practice in Edgefield, South Carolina, in 1806.
Simkins was elected as a Democratic-Republican to the Fifteenth Congress to fill the vacancy caused by the resignation of John C. Calhoun.
He served as chairman of the Committee on Public Expenditures (Sixteenth Congress).
He was interred in Cedar Fields, the family burial ground, near Edgefield, South Carolina.