First located in the basement of the Judson Memorial Church south of Washington Square, by 1924 the Center was the largest clinic of its kind in the United States.
[1] The Center provided healthcare through over one million visits to the largely Italian immigrant population between 1921 and 1957, when Campbell retired.
Campbell began her career in New York City at Metropolitan Hospital and later worked at the Mulberry Street Health Center, operated by the New York Association for Improving the Condition of the Poor and partially funded by the Milbank Memorial Fund, founded by Campbell's mother.
Responding to entreaties from Reverend Alonzo Ray Petty to attend to the needs of the many local children suffering from rickets, Campbell opened the center at the Judson Church in January, 1921.
In 1931, she founded the Deering Foundation (renamed the Eleanor A. Campbell Charitable Fund in 2016) to provide tuition support for local residents.