In 1999, she was elected as Executive Secretary of the Network of Women Sex workers of Latina America and the Caribbean (Spanish: Red de Mujeres Trabajadoras Sexuales de Latinoamérica y Caribe, RedTraSex).

The organization works for the defence, promotion, recognition and respect for human rights of sex workers in fifteen countries.

[5] Reynaga co-edited The High Heels Movement (Spanish: Un Movimiento de Tacones Altos), a manual for the defense of sex workers' rights published in 2007.

[6] Reynaga has also campaigned on issues related to health (HIV/AIDS)[7][8] In 2008, she was the first to address the issue of sex worker's rights in a plenary session of the International AIDS Conference,[9][10] where she asked for better working conditions, health care, recognition of sex work as work, and called on the audience to see sex workers not as the problem, but as "part of the solution".

[11][12] In 2009, the Buenos Aires legislature recognised Reynaga as "Outstanding Public Figure for the Human Rights of Women" (Spanish: Personalidad Destacada de los Derechos Humanos de las Mujeres).