Born in Milan, already active as a runway model, Brigliadori began her television career in 1977, as an assistant of Enzo Tortora in the RAI variety show Portobello.
[1][2] Brigliadori came to the success with the Rai Uno Saturday night show Fantastico, that she hosted alongside Pippo Baudo and Heather Parisi in 1984.
[4] In more recent years, she starred on some television reality shows, including ice-skating-themed Notti sul ghiaccio and L'Isola dei Famosi, the Italian equivalent to Survivor.
She publicly labeled chemotherapy as responsible for the death of people undergoing it, she spoke out against researchers and pharmaceuticals producers alike, also describing Italian physician Umberto Veronesi as "a doctor from hell".
[6][7] Brigliadori publicly supports pseudo-scientific treatments against tumors on her Facebook account[8] She advocates the "Hamer method", based on the assumption that diseases generate from unsolved inner conflicts.