Eleonora Luisa Gonzaga (13 November 1686 – 16 March 1741) was the Duchess of Rovere and Montefeltro as the wife of Francesco Maria de' Medici.

Eleonora Luisa Gonzaga married Francesco Maria de' Medici, Duke of Rovere and Montefeltro (titles inherited from his mother) on 14 July 1709.

[1] The House of Medici was desperately wanting in male heirs; Francesco Maria, previously a cardinal, was released from his vows through his brother's action to remedy this.

Despite requisitioning the assistance of her old confessor from Guastalla, Cosimo III could not cajole her into submitting, as she allegedly feared contracting venereal diseases.

[2] On 2 February 1711, Francesco Maria died of dropsy, leaving behind exorbitant debts.