Born in Rome, Pandolfi got a degree in accounting, and then enrolled at the Silvio d’Amico Academy of Dramatic Arts graduating in 1948.

[1] He debuted on stage the same year, and was mainly active in theater, including operetta, musical theatre and revue.

[1] Pandolfi appeared as a character actor in a number of films, mainly in humorous roles,[1] and was known for his skills as an impressionist, imitating other people (both men and women), foreign accents, and languages.

[2] Pursuing a career as a voice actor and dubber,[1] he was renowned for his ability in dubbing even female roles effectively, which sometimes led him to provide post-syncronized dialogue of a few Italian actresses.

[2][3][4] With some help from Marcello Mastroianni, later described by Pandolfi as "the best friend I ever had", he met and got to work with Federico Fellini, who hired him to voice many characters in films such as La dolce vita and 8½.