Isoardi currently hosts the daytime game show La prova del cuoco on Rai 1.

She entered the competition as the regional winner of the Miss Valle d'Aosta title.

[2] Isoardi later achieved success on Italian television hosting the early afternoon show Effetto sabato from 2007 to 2008 on Rai 1.

[3] She replaced Antonella Clerici on the television game show La prova del cuoco (the Italian version of Ready Steady Cook) from December 2008 to June 2010,[4] a position that she returned to from 2018 to 2020.

In 2015 she started dating politician and Lega Nord's leader Matteo Salvini, who became Deputy Prime Minister three years later.