She attended the Qemal Stafa Gymnasium where she earned a scholarship from the United World Colleges as one of the top five high school students in Albania and later received a diploma at the Lester B. Pearson College in Vancouver Island, Canada.

She continued her education by enrolling at the Mount Holyoke College in Massachusetts, United States where she graduated in 2005 with an honorary degree in two branches, Politics and Economics.

Elisa has travelled and studied merit scholarships to countries such as Argentina and the United Kingdom, experiences she considers invaluable in her academic formation.

On 17 January 2019, she resumed the vacant post of Minister of State for Relations with the Parliament[2] which had previously been held by Ermonela Felaj.

On July 28, 2024, Spiropali was appointed as Albania's deputy of parliament, following the resignation of Lindita Nikolla two days earlier.