Elisabeth married Duke Louis II of Brzeg-Legnica on 9 April 1418 in the city of Konstanz, during the Council where her father, then only Burgrave of Nürnberg, was elevated to the Electoral title from his Margraviate of Brandenburg.
As one of the wealthiest princes of his time, Duke Louis II also left to his wife and daughters 30,000 Rhenish guilders and 10,000 Bohemian groschen.
In 1443, Elisabeth was forced to give Brzeg to Dukes John I of Lüben and Henry X of Chojnów, sons of Louis III of Oława, who had died in 1441.
Both brothers claimed the inheritance of Duke Louis II as his lawful male heirs and because Elisabeth retained both Duchies illegally.
Shortly after Elisabeth's death, the local nobility rebelled against the Piast government and sought the help of Emperor Sigismund, who placed Legnica under the direct sovereignty of the Kingdom of Bohemia.