Elizabeth of Brunswick-Grubenhagen (20 March 1550 – 11 February 1586) was the first wife of Duke John of Schleswig-Holstein-Sonderburg, the son of King Christian III of Denmark.

Elisabeth was born on 20 March 1550.

She was the only daughter of Duke Ernest III of Brunswick-Grubenhagen and his wife, Duchess Margaret of Pomerania.

Elisabeth married the Duke John of Schleswig-Holstein-Sonderburg on 19 Aug 1568.