Her grandfather was Jan van den Eynde, a wealthy Flemish merchant, banker and art collector who purchased and renovated the Palazzo Zevallos Stigliano in 1653.

While the Palazzo Zevallos in central Naples passed to her elder sister Giovanna, who married a Colonna heir, Elisabeth was given the monumental Palazzo Vandeneynden, alongside a smaller portion of the Marquess' assets, which included his art collection, one of the largest and most valuable in Naples and its surroundings.

[8][9] Elisabeth was born into the Van den Eynde family, a powerful and influential Neapolitan noble family of Flemish origin, related to several prominent Flemish artists, including Brueghel, Jode, Lucas de Wael and Cornelis de Wael.

[16] While drawing up the inventory, Giordano counted ten paintings executed by himself in Van den Eynde's collection.

[16] On April 11, 1688,[1] just three days before her fourteenth birthday, she was married to her agemate Carlo Carafa, 3rd Prince of Belvedere, 6th Marquess of Anzi, and Lord of Trivigno.

[8][9] In 1689, Princess Elisabeth bought the fiefs of Gallicchio, Missanello, and Castiglione, whose proprietor, Gian Battista Pignatelli, was in financial trouble.

[6] When, in 1735, the new King of Naples and Sicily Charles III of Spain undertook a journey through Calabria, Apulia, Basilicata, and Sicily, in order to assess the condition of his kingdom and its people, he was shocked by the poor living conditions of the population and the overall cultural and economic backwardness in those lands.