[1] On December 20, 1881, Vanderbilt married Dr. William Seward Webb (1851–1926) at St. Bartholomew's Episcopal Church in New York City.

William was a physician and railroad executive who later became a member of the Vermont House of Representatives and was a founder, and president, of the Sons of the American Revolution.

[3] Together, Eliza and William were the parents of four children:[4] She enjoyed playing golf, contract bridge, gardening, traveling and reading.

[10] After a funeral at Trinity Church in Shelburne, she was buried alongside her late husband at Woodlawn Cemetery in the Bronx.

[1][12] She planned meals, hired servants, hosted guests, and took care of the interior decorating and garden design.