In 2025 Simon & Schuster published Kirke's debut book, a memoir-in-essays, titled Wild West Village.

[3] Her father, Simon Kirke, is a musician who served as drummer for the rock bands Bad Company and Free, and her mother, Lorraine (née Dellal), is a fashion designer.

[16] Kirke's breakout role came as the main character Hayley Rutledge in the Amazon series Mozart in the Jungle.

[18] In 2014, she had a supporting role in the David Fincher film Gone Girl,[19] before going on to star in Mistress America alongside Greta Gerwig.

[33] The album was hailed as "immediately iconic" by AllMusic,[34] and was said to bridge "the gap that once existed between Madonna and the Mandrell Sisters," by Uncut Magazine.

[37] In August 2022, it was announced that Kirke would be supporting Swedish folk duo First Aid Kit on their UK Tour in November and December 2022.

In 2017 she notably wore a "Fuck Paul Ryan" pin on her gown to the Golden Globes to protest the defunding of Planned Parenthood.

[43] Kirkus called the debut "a funny, raw, and painful book about a woman’s chaotic, thoroughly individual path to coming into her own," while Booklist praised Kirke's insights as "a delicious peek behind the veil, like an Andy Warhol Diaries for rich New York City art kids of the new millennium.