She was born in about 1510, the daughter of Rouland Brugge, died 1540, and Margery Kelom.
[1] She married Ralph Vane and in 1550 they were given Penshurst Place by the King.
Her husband was executed for plotting to kill John Dudley, 1st Duke of Northumberland in February 1552.
[2] She was in a weak position and when Queen Mary came to power she had many Protestants arrested.
Lady Fane was described by John Foxe as a "a speciall Nourse and a great supporter [within] her power of the godly Saintes, which were imprisoned in Q[ueen] Marie's time.