She made her television debut in 2011, appearing as Emily Alexander in the long-running British soap opera Hollyoaks.

In contrast to the ensemble nature of the series, the episode contained none of the main cast (except Iain De Caestecker) and was centered around Henstridge's character.

[10] In 2016, Henstridge reprised the role of Jemma Simmons in animated form in an episode of the Disney XD superhero series Ultimate Spider-Man.

[11][12] That same year, she was cast as Abigail Folger in the horror film Wolves at the Door, loosely based on the infamous Manson Family's murders.

[14] In March 2020, it was announced that she was cast in a leading role in the Apple TV+ drama thriller series Suspicion, alongside Uma Thurman.

[15] Henstridge plays Tara, a junior research fellow at Oxford and one of the suspects in the Leo Newman case.

[citation needed] In 2019, it was revealed that she was involved in an untitled superhero film that she starred, directed, wrote and produced.