Langham was born on 19 February 1635, probably at the family seat of Donington Hall.

They lived at houses at Cottesbrooke and Crosby Place in London which belonged to her father-in-law.

Her husband's brother, William, wrote her a eulogy which included the lines "That skill in Scripture, and in Tongues she got/ Made her a living Bible Polyglot".

Her step-daughter, Mary, inherited her religious devotion[1] and she would in time marry Henry Booth, first earl of Warrington.

[2] In 1683 Samuel Clarke published The Lives of Sundry Eminent Persons in this Later Age which included Langham.